Trichodysplasia Spinulosa in Gorlin Syndrome Treated With Vismodegib—Reply

Specific detection of trichodysplasia spinulosa–associated polyomavirus DNA in skin and renal allograft tissues in a patient with trichodysplasia spinulosa.

BACKGROUND Trichodysplasia spinulosa (TS) is a rare, disfiguring skin condition that affects immunosuppressed patients, universally involving the central face. New data point to the recently discovered TS-associated polyomavirus (TSPyV) as the causative agent. OBSERVATIONS We report a case of TS in a 48-year-old African American man after renal transplant; via polymerase chain reaction and se...

Trichodysplasia spinulosa: A rare complication of immunosuppression

TS: trichodysplasia spinulosa TSPyV: TS-associated polyoma virus INTRODUCTION Trichodysplasia spinulosa (TS) is a recently described rare disease of immunosuppressed patients characterized by folliculocentric papules and keratin spicules. The condition is highly associated with the TS-associated polyomavirus (TSPyV); however, the causal mechanism remains undiscovered. Currently, there is a dear...

Seroprevalence of Trichodysplasia Spinulosa–associated Polyomavirus

We identified a new polyomavirus in skin lesions from a patient with trichodysplasia spinulosa (TS). Apart from TS being an extremely rare disease, little is known of its epidemiology. On the basis of knowledge regarding other polyomaviruses, we anticipated that infections with trichodysplasia spinulosa-associated polyomavirus (TSV) occur frequently and become symptomatic only in immunocompromi...

Potential Route of Transmission for Trichodysplasia Spinulosa Polyomavirus

Discovery of a New Human Polyomavirus Associated with Trichodysplasia Spinulosa in an Immunocompromized Patient

The Polyomaviridae constitute a family of small DNA viruses infecting a variety of hosts. In humans, polyomaviruses can cause infections of the central nervous system, urinary tract, skin, and possibly the respiratory tract. Here we report the identification of a new human polyomavirus in plucked facial spines of a heart transplant patient with trichodysplasia spinulosa, a rare skin disease exc...